Prognostic significance of autocrine motility factor receptor expression by colorectal cancer and lymph node metastases - 05/05/15

Doi : 10.1016/j.amjsurg.2015.01.010

Yasmin Halwani, M.D. ^a, Liliana D. Kojic, Ph.D. ^b, Simon K. Chan, M.Sc. ^c, Terry P. Phang, M.D., M.Sc. ^a, Hamid Masoudi, M.D. ^d, Steven J.M. Jones, Ph.D. ^c, Ivan R. Nabi, Ph.D. ^b, Sam M. Wiseman, M.D. ^a,^⁎
^a Department of Surgery, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
^b Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
^c Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
^d Department of Pathology and Laboratory Medicine, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada

^∗Corresponding author. Tel.: +1-604-806-9108; fax: +1-604-806-9957.

Abstract

Background

Autocrine motility factor receptor (AMFR) has been linked to metastasis and tumorigenicity. The aim of this study was to evaluate expression and prognostic significance of AMFR in colorectal carcinoma.

Methods

AMFR expression was evaluated in 127 colon cancer specimens, 131 rectal cancer specimens, and 47 colonic and 25 rectal corresponding lymph node metastases. Clinicopathological correlates of prognostic significance were established by univariate and multivariate analysis. Spearman's correlation determined the association of expression between cancers and their metastases.

Results

AMFR was over-expressed by 22% of colon cancers and 18% of rectal cancers. AMFR over-expression correlated significantly with improved disease-free survival (DFS) (P < .05) in colon cancer and decreased DFS in corresponding nodal metastases. In rectal cancer, AMFR over-expression significantly correlated with decreased overall survival, DFS, and disease-specific survival (P < .001, P = .031, P = .005, respectively) and decreased overall survival in corresponding metastases.

Conclusion

AMFR may serve as a molecular prognosticator for colon cancer and rectal cancer.

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Keywords : Colon cancer, Rectal cancer, Tissue microarray, Autocrine motility factor receptor

Plan

Patients and Methods

Statistical analysis

Results

Autocrine motility factor receptor expression

Survival analysis

Correlation between primary colonic and rectal cancers and their associated lymph node metastases for autocrine motility factor receptor expression

Correlation between autocrine motility factor receptor expression by colon and rectal cancer primary tumors and clinicopathological variables

Comments

Conclusions

The authors declare no conflicts of interest.

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Vol 209 - N° 5

P. 884-889 - mai 2015 Retour au numéro

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Prognostic significance of autocrine motility factor receptor expression by colorectal cancer and lymph node metastases - 05/05/15

Abstract

Background

Methods

Results

Conclusion

Plan

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