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Journal of the American Society of Echocardiography

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Echocardiographic Measurements in Normal Chinese Adults Focusing on Cardiac Chambers and Great Arteries: A Prospective, Nationwide, and Multicenter Study - 04/05/15

Doi : 10.1016/j.echo.2015.01.022 
Gui-Hua Yao, MD, PhD a, Yan Deng, MD b, Yan Liu, MD, PhD a, Ming-Jun Xu, MD a, Cheng Zhang, MD, PhD a, You-Bin Deng, MD, PhD c, Wei-Dong Ren, MD, PhD d, Zhi-An Li, MD, PhD e, Hong Tang, MD f, Quan-Bin Zhang, MD g, Yu-Ming Mu, MD, PhD h, Li-Gang Fang, MD, PhD i, Mei Zhang, MD, PhD a, ⁎ , Li-Xue Yin, MD, PhD b, ⁎ , Yun Zhang, MD, PhD a, ⁎
on behalf of the

Echocardiographic Measurements in Normal Chinese Adults (EMINCA) Study Investigators

a Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China 
b Department of Cardiovascular Ultrasound and Noninvasive Cardiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China 
c Department of Medical Ultrasound, Tong Ji Hospital, Tong Ji Medical College, Hua Zhong University of Science and Technology, Wuhan, China 
d Department of Ultrasound, Affiliated Sheng Jing Hospital of China Medical University, Shenyang, China 
e Department of Echocardiography, Beijing An Zhen Hospital of Capital Medical University, Beijing, China 
f Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China 
g Department of Ultrasound, The General Hospital of Taigang Affiliated to Shanxi Medical University, Taiyuan, China 
h Department of Echocardiography, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China 
i Department of Cardiology, Peking Union Medical College Hospital, Beijing, China 

∗Reprint requests: Yun Zhang, MD, PhD, Qilu Hospital of Shandong University, Department of Cardiology, 107 Wenhuaxi Road, 250012, Jinan, China.∗∗Li-Xue Yin, MD, PhD, Department of Cardiovascular Ultrasound and Noninvasive Cardiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, 2nd West Section, 1st Roundway, 610072, Chengdu, China∗∗∗Mei Zhang, MD, PhD, Qilu Hospital of Shandong University, Department of Cardiology, 107 Wenhuaxi Road, 250012, Jinan, China

Abstract

Background

Currently available echocardiographic reference values are derived mainly from North American and European population studies, and no echocardiographic reference values are available for the Chinese population. The aim of this study was to establish normal values of echocardiographic measurements of the cardiac chambers and great arteries in a nationwide, population-based cohort of healthy Han Chinese adults.

Methods

A total of 1,586 healthy Han Chinese volunteers aged 18 to 79 years were screened at 43 collaborating laboratories throughout China. Standard M-mode and two-dimensional echocardiography was performed to obtain measurements of the cardiac chambers and great arteries. The impacts of gender and age on all echocardiographic measurements were analyzed.

Results

A total of 1,394 qualified healthy subjects (mean age, 47.3 ± 16.0 years; 678 men) were ultimately enrolled. Except for left ventricular ejection fraction, values of cardiac chamber and great arterial dimensions were significantly higher in men than in women. Most measurements of the atrial and great arterial dimensions, left ventricular wall thickness, and left ventricular mass increased with age in both men and women.

Conclusions

Normal reference values of cardiac dimensional parameters were established for the first time in a nationwide, population-based cohort of healthy Han Chinese adults. Because most of these parameters were found to vary with gender and age, reference values stratified for gender and age should be used in clinical practice.

Le texte complet de cet article est disponible en PDF.

Keywords : Echocardiography, Cardiac chamber, Great arteries, Normal reference values, Chinese adults

Abbreviations : ASE, BSA, DBP, EMINCA, IVSd, IVSs, LA, LA-ap, LAV, LV, LVEDD, LVEDV, LVEF, LVM, LVPWd, LVPWs, RA, RA-l, RA-t, RV, SBP


Plan


 This work was supported by research grants from the National 973 Basic Research Program (grants 2011CB503906, 2012CB518603, and 2013CB530703), the National High-Tech Research and Development Program of China (grant 2012AA02A510), the Program of Introducing Talents of Discipline to Universities (grant B07035), the State Program of National Natural Science Foundation of China for Innovative Research Group (grant 81321061), the State Key Program of National Natural Science of China (grant 61331001), the International Collaboration and Exchange Program of China (grant 81320108004), and the National Natural Science Foundation of China (grants 81425004, 91339109, 81173251, 81270350, 81300234, 81300217, 81100147, 81170136, 81170275, and 81270403).
 Drs G.-H. Yao, Y. Deng, and Y. Liu contributed equally to this work. See the Appendix for a list of EMINCA investigators.


© 2015  American Society of Echocardiography. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 28 - N° 5

P. 570-579 - mai 2015 Retour au numéro
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