Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt - 11/04/15
, Mohamed Hashem a, Doa'a A. Saleh b, Mohamed Ehab c, Sahar A. Sharaf d, Fatma El-Mougy d, Lobna Abdelsalam d, Ravi Jhaveri e, Ahmed Aboulnasr c, Hesham El-Ghazaly cSummary |
Objectives |
The Centers for Disease Control and Prevention (CDC) only recommends risk-based HCV screening for pregnant women in the United States. This study sought to determine the reliability of risk-based versus universal HCV screening for pregnant women in Egypt, a country with the world's highest HCV prevalence that also relies on risk-based screening, and to identify additional characteristics that could increase the reliability of risk-based screening.
Methods |
Pregnant women attending the Cairo University antenatal clinic were tested for anti-HCV antibodies and RNA, and demographic characteristics and risk factors for infection were assessed.
Results |
All 1250 pregnant women approached agreed to participate (100%) with a mean age of 27.4 ± 5.5 years (range:16–45). HCV antibodies and RNA were positive in 52 (4.2%) and 30 (2.4%) women respectively. After adjustment, only age (OR:1.08, 95%CI:1.002–1.16, p < 0.01), history of prior pregnancies (OR:1.20, 95%CI:1.01–1.43, p < 0.04), and working in the healthcare sector (OR:8.68, 95%CI:1.72–43.62, p < 0.01), remained significantly associated with chronic HCV infection.
Conclusions |
Universal antenatal HCV screening was widely accepted (100%) and traditional risk-based screening alone would have missed 3 (10%) chronically infected women, thereby supporting universal screening of pregnant women whenever possible. Otherwise, risk-based screening should be modified to include history of prior pregnancy and healthcare employment.
Le texte complet de cet article est disponible en PDF.Highlights |
• | In this study, we compare universal and risk-based HCV screening in pregnant women. |
• | We examine whether additional risk factors can increase the chronic HCV detection. |
• | Universal screening for HCV was offered to, and accepted by, all pregnant women. |
• | Traditional risk-based screening would have missed 10% of those with chronic HCV. |
• | Past pregnancy and healthcare sector employment were associated with chronic HCV. |
Keywords : Pregnancy, Hepatitis C, Mass screening, Egypt, Risk factors
Plan
Vol 70 - N° 5
P. 512-519 - mai 2015 Retour au numéro
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