Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis - 13/03/15
Doi : 10.1016/j.tube.2015.01.001
Elizabeth García, María V. Bianco, María José Gravisaco, Rosana V. Rocha, Federico C. Blanco, Fabiana Bigi ⁎ 
Instituto de Biotecnología, CICVyA-INTA, N. Repetto and De los Reseros, 1686 Hurlingham, Argentina
∗Corresponding author.
Summary |
In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccination with the double mutant protected mice against challenge with a virulent M. bovis strain.
Le texte complet de cet article est disponible en PDF.Keywords : Vaccine, phoP, Bovine tuberculosis, Mycobacerium bovis
Plan
© 2015
Elsevier Ltd. Tous droits réservés.
Vol 95 - N° 2
P. 186-189 - mars 2015 Retour au numéro
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