Allergy to furry animals: New insights, diagnostic approaches, and challenges - 05/03/15
, Takao Fujisawa, MD, PhD d, Marianne van Hage, MD, PhD e, Gunilla Hedlin, MD, PhD a, b, c, Christiane Hilger, PhD f, Jörg Kleine-Tebbe, MD g, Elizabeth C. Matsui, MD, MHS h, Graham Roberts, DM, MRCPCH i, j, k, Eva Rönmark, PhD l, Thomas A.E. Platts-Mills, MD, PhD mAbstract |
The prevalence of allergy to furry animals has been increasing, and allergy to cats, dogs, or both is considered a major risk factor for the development of asthma and rhinitis. An important step forward in the diagnosis of allergy to furry animals has been made with the introduction of molecular-based allergy diagnostics. A workshop on furry animals was convened to provide an up-to-date assessment of our understanding of (1) the exposure and immune response to the major mammalian allergens, (2) the relationship of these responses (particularly those to specific proteins or components) to symptoms, and (3) the relevance of these specific antibody responses to current or future investigation of patients presenting with allergic diseases. In this review research results discussed at the workshop are presented, including the effect of concomitant exposures from other allergens or microorganisms, the significance of the community prevalence of furry animals, molecular-based allergy diagnostics, and a detailed discussion of cat and dog components.
Le texte complet de cet article est disponible en PDF.Key words : Molecular-based allergy diagnostics, allergy, allergens, furry animals, cats, dogs, allergic asthma, allergic rhinitis, pork-cat syndrome
Abbreviation used : Alpha-gal
Plan
| Thermo Fisher Scientific (Uppsala) sponsored the workshop on furry animals, but the company did not contribute to the writing of the report from the workshop. |
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| Disclosure of potential conflict of interest: J. R. Konradsen has received travel support from Thermo Fisher Scientific, research support from Novartis, and payment for lectures from Novartis, Thermo Fisher, and Meda. M. van Hage has received consultancy fees from Hycor Biomedical and lecture fees from Thermo Fisher Scientific, Novartis, and ALK-Abelló. G. Hedlin has received lecture fees from Thermo Fisher. C. Hilger, J. Kleine-Tebbe, and E. Rönmark have received travel support from Thermo Fisher Scientific. E. C. Matsui has received travel support from Thermo Fisher, is on the US Environmental Protection Agency's Science Advisory Board, and has received research support from the National Institutes of Health. G. Roberts has received research support from Thermo Fisher in the form of providing assay reagents. T. A. E. Platts-Mills has received travel support from Phadia and research support from Thermo Fisher. T. Fujisawa declares no relevant conflicts of interest. |
Vol 135 - N° 3
P. 616-625 - mars 2015 Retour au numéro
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