Risk factors for false-negative T-SPOT.TB assay results in patients with pulmonary and extra-pulmonary TB - 01/03/15
Summary |
Objectives |
To investigate the risk factors for false-negative T-SPOT.TB results in patients with pulmonary TB (PTB) and extra-pulmonary TB (EPTB).
Methods |
Patients with suspected TB who underwent valid T-SPOT.TB tests were prospectively enrolled at Beijing Chest Hospital between November 2012 and November 2013. Basic characters and clinical laboratory findings were compared between true-positive and false-negative T-SPOT.TB groups.
Results |
Of 1928 suspected TB patients, 774 (530 PTB and 244 EPTB) microbiologically/histopathogenically-confirmed patients (636 culture-confirmed) were analyzed. Forty-six PTB patients (8.7%) and 32 EPTB patients (13.1%) had negative T-SPOT.TB results. Multivariate analysis showed that increased age [odds radio (OR) 2.26, 95% confidence interval (CI) 1.11–4.58], over-weight (BMI ≥ 25 kg/m2, OR 2.43, 95% CI 1.05–5.63), and a longer period of illness before hospitalization (>6 months, OR 2.46, 95% CI 1.24–4.92) were independent risk factors for false-negative T-SPOT.TB results in PTB patients. In EPTB patients, increased age (OR 2.42, 95% CI 1.09–5.35) also showed an independent association with false-negative T-SPOT.TB results.
Conclusion |
Careful interpretation of negative T-SPOT.TB results is necessary in older patients with suspected PTB or EPTB, and in PTB patients who are over-weight or have had longer periods of illness before hospitalization.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Increased age is a risk factor for false-negative T-SPOT.TB results in PTB and EPTB. |
• | Over-weight is a risk factor for false-negative T-SPOT.TB results in PTB. |
• | Longer period of illness is a risk factor for false-negative T-SPOT.TB in PTB. |
• | PTB and EPTB are different in the risk factors for false-negative T-SPOT.TB results. |
Keywords : Pulmonary TB, Extra-pulmonary TB, T-SPOT.TB, False-negative, Risk factor
Plan
Vol 70 - N° 4
P. 367-380 - avril 2015 Retour au numéro
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