Serum Anti-Tissue Transglutaminase Antibodies Detected during Febrile Illness May Not Be Produced by the Intestinal Mucosa - 25/02/15
Doi : 10.1016/j.jpeds.2014.12.005
Luigina De Leo, PhD 1, ∗, Sara Quaglia, PhD 1, ∗, Fabiana Ziberna, PhD 1, Serena Vatta, BSc 1, Stefano Martelossi, MD 1, Massimo Maschio, MD 1, Tarcisio Not, MD 1, 2, ⁎ 
1 Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Trieste, Italy
2 University of Trieste, Trieste, Italy
∗Reprint requests: Tarcisio Not, MD, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo,” Via dell'Istria 65/1, 34100 Trieste, Italy.
Abstract |
Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.
Le texte complet de cet article est disponible en PDF.Keyword : AEA, anti-TG
Plan
| Supported by Ministero della Salute (RF 203/2010 [to T.N.]). The authors declare no conflicts of interest. |
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| Registered with ClinicalTrials.gov: NCT00677495. |
© 2015
Elsevier Inc. Tous droits réservés.
Vol 166 - N° 3
P. 761-763 - mars 2015 Retour au numéro
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