Environmental Rather than Genetic Factors Determine the Variation in the Age of the Infancy to Childhood Transition: A Twins Study - 25/02/15
, Gregory Livshits, PhD 2, Inga Peter, PhD 3, Ida Malkin, PhD 2, Jonathan Dubnov, MD 4, Hannah Akons, MD 5, Michael Shmoish, PhD 6, Ze'ev Hochberg, MD, PhD 7Abstract |
Objective |
Using a twins study, we sought to assess the contribution of genetic against environmental factor as they affect the age at transition from infancy to childhood (ICT).
Study design |
The subjects were 56 pairs of monozygotic twins, 106 pairs of dizygotic twins, and 106 pairs of regular siblings (SBs), for a total of 536 children. Their ICT was determined, and a variance component analysis was implemented to estimate components of the familial variance, with simultaneous adjustment for potential covariates.
Results |
We found substantial contribution of the common environment shared by all types of SBs that explained 27.7% of the total variance in ICT, whereas the common twin environment explained 9.2% of the variance, gestational age 3.5%, and birth weight 1.8%. In addition, 8.7% was attributable to sex difference, but we found no detectable contribution of genetic factors to inter-individual variation in ICT age.
Conclusions |
Developmental plasticity impacts much of human growth. Here we show that of the ∼50% of the variance provided to adult height by the ICT, 42.2% is attributable to adaptive cues represented by shared twin and SB environment, with no detectable genetic involvement.
Le texte complet de cet article est disponible en PDF.Keyword : DICT, DZ, GH, ICT, MZ, SB
Plan
| The authors declare no conflicts of interest. |
Vol 166 - N° 3
P. 731-735 - mars 2015 Retour au numéro
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