Pressure-Flow Characteristics of Normal and Disordered Esophageal Motor Patterns - 25/02/15
, Stamatiki Kritas, BSc 2, 3, ∗, Charles Cock, MD 4, Lara F. Ferris, MSc 2, Lisa McCall, RN 2, Nathalie Rommel, PhD 3, 5, Michiel P. van Wijk, MD, PhD 1, Marc A. Benninga, MD, PhD 1, David Moore, MD 6, Taher I. Omari, PhD 2, 4, 7Abstract |
Objective |
To perform pressure-flow analysis (PFA) in a cohort of pediatric patients who were referred for diagnostic manometric investigation.
Study design |
PFA was performed using purpose designed Matlab-based software. The pressure-flow index (PFI), a composite measure of bolus pressurization relative to flow and the impedance ratio, a measure of the extent of bolus clearance failure were calculated.
Results |
Tracings of 76 pediatric patients (32 males; 9.1 ± 0.7 years) and 25 healthy adult controls (7 males; 36.1 ± 2.2 years) were analyzed. Patients mostly had normal motility (50%) or a category 4 disorder and usually weak peristalsis (31.5%) according to the Chicago Classification. PFA of healthy controls defined reference ranges for PFI ≤142 and impedance ratio ≤0.49. Pediatric patients with pressure-flow (PF) characteristics within these limits had normal motility (62%), most patients with PF characteristics outside these limits also had an abnormal Chicago Classification (61%). Patients with high PFI and disordered motor patterns all had esophagogastric junction outflow obstruction.
Conclusions |
Disordered PF characteristics are associated with disordered esophageal motor patterns. By defining the degree of over-pressurization and/or extent of clearance failure, PFA may be a useful adjunct to esophageal pressure topography-based classification.
Le texte complet de cet article est disponible en PDF.Keyword : AIM, DCI, DL, EPT, GERD, HRIM, IBP, IR, IRP4s, PBS, PeakP, PF, PFA, PFI, PNadImp, Pre-LAGB, TNadImp-PeakP, UES
Plan
| M.S. was supported by a travel grant from the Dutch Digestive Diseases Foundation. M.v.W. and T.O. were guest speakers for Medical Measurement Systems (Enschede, The Netherlands). The other authors declare no conflicts of interest. |
Vol 166 - N° 3
P. 690 - mars 2015 Retour au numéro
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