Oxidative stress in obstructive sleep apnea and intermittent hypoxia – Revisited – The bad ugly and good: Implications to the heart and brain - 06/02/15
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Summary |
Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is linked with increased reactive oxygen species/reactive nitrogen species (ROS/RNS) and oxidative stress, which adversely affect the associated cardio-/cerebro-vascular disease in OSA. Yet, animal and a small number of human studies support activation of cardio-/cerebro-protective mechanisms as well. ROS/RNS are intricate and multifaceted molecules with multiple functions. At low-moderate concentrations ROS/RNS are considered “good”, by regulating vital cellular functions. At higher levels, they are considered “bad” by promoting oxidative stress and damaging vital macromolecules through ischemia and reperfusion (I/R) injury. Subsequently, ROS/RNS can get “ugly” by eliciting sterile inflammation and a multitude of deadly pathologies. What makes ROS/RNS good, bad, or ugly? A dynamic interplay between a large number of factors determines the outcomes. These include the types of ROS/RNS produced, their quantity, duration, frequency, intracellular localization, micro-environmental antioxidants, as well as the genetic make-up and life style related variables. This review presents the currently available data on redox biology in physiological/pathophysiological conditions and in OSA/IH, in order to better understand the apparently contradictory findings on damage vs. repair. These findings are discussed within the context of the prevailing views on I/R associated ROS/RNS, and their potential implications to OSA.
Le texte complet de cet article est disponible en PDF.Keywords : Obstructive sleep apnea, Oxidative stress, ROS/RNS, Anti-oxidants, Ischemia/reperfusion, Ischemic preconditioning, Acute myocardial infarction, Stroke, Endothelial progenitor cells, Coronary collaterals
Plan
Vol 20
P. 27-45 - avril 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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