Toxoplasma gondii is a potential cause of anterior uveitis, posterior uveitis, or retinitis in a number of animal species, most commonly the cat. Chorioretinitis is often seen in cats with evidence of generalized toxoplasmosis. Additionally, T. gondii has been incriminated in many cases of idiopathic anterior uveitis in cats, although this is a controversial issue and the parasite may be capable of inciting an immune-mediated inflammation in ocular tissues. Despite recent advances in diagnostic techniques and new antiprotozoal pharmacologic agents, ocular toxoplasmosis remains a difficult disease to diagnose and treat.