A comparison of postoperative effects of bariatric surgery on medical markers of morbidity - 02/12/14
, Andrew J. Nagy, B.S. b, Daniel C. Jupiter, Ph.D. c, Joaquin A. Rodriguez, M.D. d, Richard E. Symmonds, M.D. d, Robert O. Carpenter, M.D., M.P.H. dAbstract |
Background |
Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported.
Methods |
Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year.
Results |
There was a decrease in serum LDL-P levels, averaging 472.58 (P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight.
Conclusion |
LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.
Le texte complet de cet article est disponible en PDF.Keywords : Bariatric surgery, LDL particle, Cholesterol, Obesity, Cardiovascular risk
Plan
| The authors declare no conflicts of interest. |
Vol 208 - N° 6
P. 897-902 - décembre 2014 Retour au numéro
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