Cardiometabolic Phenotype in Children with Obesity - 21/11/14
, Nicola Moio, MD 2, Gerolamo Sibilio, MD 2, Luigi Cavuto, MD 2, Eduardo Sanguigno, MD 3, Claudia Forziato, MD 3, Giovanni de Simone, MD 4, Brunella Capaldo, MD 5Abstract |
Objectives |
To investigate the anthropometric and metabolic correlates of different patterns of left ventricular (LV) geometry in a cohort of outpatient children with high prevalence of obesity.
Study design |
Anthropometric measures, lipid profile, blood pressure (BP), fasting plasma glucose (FPG), and echocardiographic variables were evaluated in 281 white children (6-16 years), of whom 105 were obese and 105 were morbidly obese. Patterns of LV geometry were defined as follows: normal geometry, eccentric LV hypertrophy (LVH), concentric LV remodeling, and concentric LVH.
Results |
One hundred forty-eight children exhibited normal LV geometry, 53 eccentric LVH, 36 concentric LV remodeling, and 44 concentric LVH. The 4 groups differed in body mass index, waist circumference, waist-to-height ratio, triglycerides/high-density lipoprotein cholesterol ratio (Tg/HDL-C), and BP (P < .05-.0001). A statistically significant impairment of diastolic function (expressed as greater E/E′, P < .002) was observed across patterns of LV geometry. Among anthropometric measures, waist-to-height ratio showed better performance in relation to LVH, with an optimal cut-point of 0.58, compared with body mass index and waist circumference. Children with concentric LVH exhibited the worst metabolic risk profile, with greater prevalence of visceral obesity, high Tg/HDL-C, high BP, and high-normal FPG, than children with normal LV geometry.
Conclusions |
In children with high levels of obesity, an unfavorable “cardiometabolic phenotype” can be identified, which includes concentric LVH, visceral obesity, high BP, high Tg/HDL-C, and high-normal FPG.
Le texte complet de cet article est disponible en PDF.Keyword : BMI, BP, CV, FPG, HDL-C, HOMA-IR, LV, LVDD, LVH, LVM, LVMi, RWT, TDI, Tg, WC, WhtR
Plan
| The authors declare no conflicts of interest. |
Vol 165 - N° 6
P. 1184-1189 - décembre 2014 Retour au numéro
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