MAM-2201 (Analytically Confirmed) Intoxication After “Synthacaine” Consumption - 20/11/14
, Eleonora Buscaglia, PharmD a, Pietro Papa, PhD c, Antonella Valli, PhD c, Teresa Coccini, PhD b, Andrea Giampreti, MD a, Valeria Margherita Petrolini, MD a, Sarah Vecchio, MD a, Giovanni Serpelloni, MD d, Carlo Alessandro Locatelli, MD aAbstract |
Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension (160/80 mm Hg) without ECG abnormalities were observed in a 20-year-old subject 6 hours after nasal insufflation (snorting) of a “legally” obtained white powdered substance sold as Synthacaine. A serum sample was found to contain MAM-2201 (11 ng/mL), a synthetic cannabinoid receptor agonist, and benzocaine. The patient's symptoms improved after administration of diazepam and intravenous fluids. Synthacaine was sold as legal cocaine, suggesting the user can expect an effect like that of cocaine. The pharmacologic receptor profile and chemical structure of MAM-2201 is similar to the synthetic cannabinoid receptor agonists AM-2201 and JWH-122 (2 potent synthetic cannabinoid receptor agonists with high affinity to cannabinoid receptors).
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| Supervising editor: Richard C. Dart, MD, PhD |
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| Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org/). The authors have stated that no such relationships exist. This publication arises from the activities of the Italian National Early Warning System Alert Project that received funding from Department for Antidrug Policies–Presidency of the Council of Ministers, Rome, Italy. |
Vol 64 - N° 6
P. 629-632 - décembre 2014 Retour au numéro
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