Synthesis, characterization and cytotoxic activity of novel Cu(II) and Co(II) complexes with 3-amino-5,5-dimethylhydantoin - 08/11/14
, Diana Wesselinova cBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 9 |
| Iconographies | 11 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Novel mixed complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were synthesized and their in vitro anticancer activity was investigated. The structures of the compounds were confirmed by IR, UV–Vis spectrometry, voltammetry and elemental analysis. The cytotoxic effects of novel complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were tested against a panel of human tumor cell lines. All of the compounds investigated exhibited different concentration-dependent antiproliferative effects against the HT29, MDA-MB-231, HepG2 and HeLa cell lines after 24h of treatment. The most sensitive cells were the HepG2 cells at various concentrations of both tested compounds followed by HT29.
Le texte complet de cet article est disponible en PDF.Keywords : Copper and cobalt complexes, 5,5-Disubstituted hydantoins, Cytotoxic activity, Human tumor cell lines, Voltammetry
Plan
Vol 17 - N° 12
P. 1212-1220 - décembre 2014 Retour au numéro
Article précédent
- Thiol-functionalized hierarchical zeolite nanocomposite for adsorption of Hg2+ from aqueous solutions
- Oranous Fardmousavi, Hossein Faghihian
- A proton transfer and a cobalt(II) compound including 2,6-pyridinedicarboxylate and o-phenylenediamine ions: Synthesis, characterization, crystal structure and solution study
- Khaled Ghasemi, Ali R. Rezvani, Ardeshir Shokrollahi, Abolghasem Moghimi, Sara Gavahi, Santiago García-Granda, Rafael Mendoza-Meroño
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?