Increased Plasma Incretin Concentrations Identifies a Subset of Patients with Persistent Congenital Hyperinsulinism without KATP Channel Gene Defects - 24/10/14
Doi : 10.1016/j.jpeds.2014.09.019
Yanqin Shi, PhD 1, Hima B. Avatapalle, MBChB 2, Mars S. Skae, MBChB, MPhil 2, Raja Padidela, MD 2, Melanie Newbould, FRCPath 3, Lindsey Rigby, BSc, RGN, RSCN 2, Sarah E. Flanagan, PhD 4, Sian Ellard, PhD, FRCPath 4, Jacques Rahier, MD, PhD 5, Peter E. Clayton, MBChB, MD 2, 6, Mark J. Dunne, PhD 1, Indraneel Banerjee, MD 2, Karen E. Cosgrove, PhD 1, ⁎ 
1 Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
2 Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
3 Department of Pediatric Histopathology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
4 Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom
5 Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium
6 Manchester Academic Health Science Centre, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom
∗Reprint requests: Dr Karen E. Cosgrove, PhD, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
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Disponible en ligne depuis le Friday 24 October 2014
Abstract |
Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.
Le texte complet de cet article est disponible en PDF.Keyword : CHI, CHI-A, CHI-D, CHI-F, GIP, GLP-1
Plan
| Funded by a National Institute for Health Research Manchester Biomedical Research Centre award (R00388 [to K.C. who was supported by a Research Councils UK Academic Fellowship]) and the National Institute for Health Research UK (NIHR CRF 20121115 [to M.D., I.B., K.C.]). The authors declare no conflicts of interest. |
© 2014
The Authors. Publié par Elsevier Masson SAS. Tous droits réservés.
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