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Assessing the validity of the RAND Negative Impact of Asthma on Quality of Life Short Forms - 02/10/14

Doi : 10.1016/j.jaci.2014.03.002 
Cathy D. Sherbourne, PhD a, , Brian D. Stucky, PhD a, Maria Orlando Edelen, PhD a, Nicole K. Eberhart, PhD a, Eric Kleerup, MD b, Marielena Lara, MD, MPH a
a RAND Corporation, Santa Monica, Calif 
b David Geffen School of Medicine, Division of Pulmonary and Critical Care Medicine, University of California–Los Angeles, Los Angeles, Calif 

Corresponding author: Cathy D. Sherbourne, PhD, The RAND Corporation, 1776 Main St, PO Box 2138, Santa Monica, CA 90407-2138.

Abstract

Background

In response to recommendations from the 2010 National Institutes of Health Asthma Outcomes Workshop, we developed a system for measuring the negative impact of asthma on quality of life (QoL), which was referred to as the RAND Negative Impact of Asthma on Quality of Life (RAND-IAQL) item bank. The bank contains 65 items that focus on the patient's perception of the impact or bother of asthma on his or her life.

Objective

Evidence for the validity of 2 short forms, the RAND-IAQL 4-item and 12-item Short Forms, from the bank is presented.

Methods

Using a sample of 2032 adults with asthma, we validated our short forms against the Asthma Quality of Life Questionnaire–Marks (AQLQ-M), the Asthma Control Test, and generic measures of QoL developed by the Patient-reported Outcomes Measurement Information System (PROMIS). Discriminant validity was examined by comparing scores of respondents who differed according to multiple health indicators.

Results

Our sample ranged in age from 18 to 99 years (mean, 43 years), with 14% Hispanic, 11% Asian, 19% African American, and 56% non-Hispanic white race/ethnicity. Men had a significantly worse impact of asthma on QoL than women. The impact of asthma on QoL was greatest in African American and Hispanic subjects compared with that seen in non-Hispanic white subjects. Our measures correlated highly with the AQLQ-M and more strongly with the PROMIS global physical than mental scales. They differentiated between adults with asthma according to their perceived severity, level of control, presence or absence of exacerbations, and physical comorbidity.

Conclusion

The RAND-IAQL item bank, measuring the impact of asthma on QoL, will complement other patient-reported outcomes, such as measures of asthma symptoms, functioning, and control.

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Key words : Validity, asthma, quality of life, short forms

Abbreviations used : ACT, AQLQ-M, COPD, PROMIS, QoL, RAND-IAQL-4, RAND-IAQL-12


Plan


 Supported by grant R01HL107312 from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
 Disclosure of potential conflict of interest: C. D. Sherbourne, B. D. Stucky, M. O. Edelen, and N. K. Eberhart have received research support from the National Heart, Lung, and Blood Institute (NHLBI). E. Kleerup has received research support from the NHLBI, Boehringer Ingelheim, Cephalon (Teva), Novartis, Pearl, Sunovion (Sepracor), GlaxoSmithKline, Actelion, and Forest. M. Lara has received research and travel support from the NHLBI and is employed by, has received research support from, and has received payment for manuscript preparation from the National Institutes of Health.


© 2014  American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 134 - N° 4

P. 900-907 - octobre 2014 Retour au numéro
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