To analyze variations in urinary stone composition between Uyghur and Han patients with urolithiasis in Xinjiang, China, and to explore the possible factors associated with urinary stone composition in Uyghur and Han patients.

We analyzed the components of urinary stones in 317 adults (152 Uyghur and 165 Han) with urolithiasis admitted to our hospital from March 2009 to June 2011. Urinary stones were collected by endoscopic or open surgical procedures and analyzed by infrared spectroscopy. Also analyzed were clinical data, including patient's age, sex, geographic distribution, blood tests, and urine tests. Logistic regression was performed to analyze the association between stone components and the clinical characteristics of the patients.

There were significant differences between Uyghur and Han patients in age, geographic distribution, serum concentrations of uric acid, potassium, and phosphorus, urine magnesium concentrations, 24-hour volumes of urine, and in stone components of calcium oxalate monohydrate, calcium oxalate dihydrate plus carbapatite, and uric acid. Differences in sex, family history, complications, sites of calculi, or other blood and urine test results were not significant. Logistic regression analysis revealed that geographic location, ethnicity, blood potassium concentration, and urine volume were significantly correlated with the calcium oxalate dihydrate plus carbapatite component of urinary stones.

Urinary stone composition differs between Uyghur and Han patients with urolithiasis, possibly as a result of geographic distribution.