Axillary burden of disease following false-negative preoperative axillary evaluation - 22/09/14
Abstract |
Background |
Preoperative axillary ultrasound (AUS) and fine-needle aspiration (FNA) are sensitive and specific for breast cancer nodal metastases. We hypothesize that false-negative result predicts minimal axillary disease (≤2 +nodes).
Methods |
A retrospective review of breast cancer patients receiving AUS identified T1/T2 tumors and positive sentinel node with axillary dissection. Chi-square analysis was performed using Fisher's exact test.
Results |
Of 903 AUS cases, 384 had T1/T2 tumors. False-negative rate of AUS ± FNA was 48% and 45%, respectively. Of 384 cases, 73 were sentinel node positive and had axillary dissection; 55 (75.3%) were invasive ductal carcinoma (IDC). Negative predictive value for greater than or equal to 2 nodes was 71% in IDC versus 44% for in non-IDC patients. Sixteen (29.0%) IDC patients had greater than or equal to 3 positive nodes versus 10 (55.5%) non-IDC (P = .05) patients.
Conclusion |
The high negative predictive value for AUS with FNA for IDC suggests that the AUS plus FNA interpretation may be better limited to the ipsilateral nodes of IDC.
Le texte complet de cet article est disponible en PDF.Keywords : False negative, Pathologic burden, Axillary ultrasound
Plan
There were no relevant financial relationships or any sources of support in the form of grants, equipment, or drugs. |
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The authors declare no conflicts of interest. |
Vol 208 - N° 4
P. 577-581 - octobre 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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