Immunoinformatics study on highly expressed Mycobacterium tuberculosis genes during infection - 19/09/14
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Summary |
The most important targets for vaccine development are the proteins that are highly expressed by the microorganisms during infection in-vivo. A number of Mycobacterium tuberculosis (Mtb) proteins are also reported to be expressed in-vivo at different phases of infection. In the present study, we analyzed multiple published databases of gene expression profiles of Mtb in-vivo at different phases of infection in animals and humans and selected 38 proteins that are highly expressed in the active, latent and reactivation phases. We predicted T- and B-cell epitopes from the selected proteins using HLAPred for T-cell epitope prediction and BCEPred combined with ABCPred for B-cell epitope prediction. For each selected proteins, regions containing both T- and B-cell epitopes were identified which might be considered as important candidates for vaccine design against tuberculosis.
Le texte complet de cet article est disponible en PDF.Keywords : Mycobacterium tuberculosis, Gene expression, Epitope prediction
Plan
Vol 94 - N° 5
P. 475-481 - septembre 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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