EPA-0819 - Association of csfr2a gene rs4129148 and il3ra gene rs6603272 variants with schizophrenia - 01/08/14
Résumé |
Introduction |
Schizophrenia is a devistating disorder which has a genetic component. Recently three reports showed that the IL3 gene, CSF2RA gene are associated with schizophrenia.
Aims |
The objective of the study was to show whether there was an association between the IL3R gene rs6603272 variant and the CSF2RA rs4129148 variants with schizophrenia.
Methods |
There was 264 schizophrenia patients and 222 controls from Romania. We utilized a PCR-RFLP method to genotype the subjects.
Results |
The genotype frequencies of the IL3RA rs6603272 variant were TT, 54.2; TG, 39.8; and GG,6.1 % in cases and TT, 52.7; TG, 41.9; and GG,5.4 % in controls. The T allele frequency in both controls and cases was 74%. The genotype frequencies of the CSF2RA gene rs4129148 variant were GG, 40.2;GC,51.1; and CC, 8.7 % in cases and GG,39.2; GC,45.5; and CC,15.3 % in controls. The G allele frequency was 66% in cases and 62% in controls.
Conclusion |
The IL3RA gene rs6603272 variant was not associated with schizophrenia(X2=0.271; P=0.873). However The CSF2RA gene rs4129148 variant CC genotype was associated with schizophrenia(X2=5.079; P=0.024). The G allele was agenetic risk factor for schizophrenia (X2=5.079; P=0.024; OR=1.895, 95%CI= 1.080- 3.326). The controls were in Hardy-Weinberg equilibrium. But cases were not.
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