Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006 - 01/08/14
Abstract |
Background |
Allergic sensitization is an important risk factor for the development of atopic disease. The National Health and Nutrition Examination Survey (NHANES) 2005-2006 provides the most comprehensive information on IgE-mediated sensitization in the general US population.
Objective |
We investigated clustering, sociodemographic, and regional patterns of allergic sensitization and examined risk factors associated with IgE-mediated sensitization.
Methods |
Data for this cross-sectional analysis were obtained from NHANES 2005-2006. Participants aged 1 year or older (n = 9440) were tested for serum specific IgEs (sIgEs) to inhalant and food allergens; participants 6 years or older were tested for 19 sIgEs, and children aged 1 to 5 years were tested for 9 sIgEs. Serum samples were analyzed by using the ImmunoCAP System. Information on demographics and participants' characteristics was collected by means of questionnaire.
Results |
Of the study population aged 6 years and older, 44.6% had detectable sIgEs, whereas 36.2% of children aged 1 to 5 years were sensitized to 1 or more allergens. Allergen-specific IgEs clustered into 7 groups that might have largely reflected biological cross-reactivity. Although sensitization to individual allergens and allergen types showed regional variation, the overall prevalence of sensitization did not differ across census regions, except in early childhood. In multivariate modeling young age, male sex, non-Hispanic black race/ethnicity, geographic location (census region), and reported pet avoidance measures were most consistently associated with IgE-mediated sensitization.
Conclusions |
The overall prevalence of allergic sensitization does not vary across US census regions, except in early life, although allergen-specific sensitization differs based on sociodemographic and regional factors. Biological cross-reactivity might be an important but not the sole contributor to the clustering of allergen-specific IgEs.
Le texte complet de cet article est disponible en PDF.Key words : Allergen, allergy, allergic sensitization, serum IgE
Abbreviations used : GM, NCHS, NHANES, SES, sIgE
Plan
| Supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences. |
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| Disclosure of potential conflict of interest: S. J. Arbes has received a grant from the National Institute of Allergy and Infectious Disease/Division of Allergy, Immunotherapy, and Transplantation/National Institutes of Health. A. H. Liu is on the Data Safety Monitoring Committee for GlaxoSmithKline, has consultant arrangements with DBV, and has received payment for lectures from Merck. The rest of the authors declare that they have no relevant conflicts of interest. |
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| The findings and conclusions in this article are those of the author or authors and do not necessarily represent the views of the Research Data Center, the NCHS, or the Centers for Disease Control and Prevention. |
Vol 134 - N° 2
P. 350-359 - août 2014 Retour au numéro
Article précédent
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- Robert G. Hamilton
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