?-aminolevulinate dehydratase activity in lung cancer patients and its relationship with oxidative stress - 31/07/14
, Luana Paula Pelinson a, Roberta Schmatz a, Luciane Belmonte Pereira a, Caroline Curry Martins a, Jucimara Baldissareli a, Guilherme Pires Amaral a, Félix Alexandre Antunes Soares a, Luiz Gustavo Brenner Reetz b, Maria do Carmo Araújo b, Juarez Chiesa b, Vera Maria Morsch a, Daniela Bitencourt Rosa Leal a, Maria Rosa Chitolina Schetinger a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
This study investigated the δ-aminolevulinate dehydratase (δ-ALA-D) activity in whole blood as well as the parameters of oxidative stress, such as reactive species (RS) levels in serum, thiobarbituric acid reactive substances (TBARS) levels, the superoxide dismutase (SOD) and catalase (CAT) activities, as well as total thiols (T-SH) and non-protein thiols (NPSH) levels in platelets. Moreover, the content of vitamin C and E in plasma and serum, respectively, in lung cancer patients was also investigated. We collected blood samples from patients (n=28) previously treated for lung cancer with chemotherapy. Patients were classified as stage IIIb and IV according to the Union for International Cancer Control (UICC). Results showed a decrease of 37% in δ-ALA-D activity in patients with lung cancer when compared to the control group. RS and TBARS levels were 8% and 99% higher in the patient group, respectively. The activity of SOD and CAT as well as the vitamin C content were 41%, 35% and 127% lower in patients when compared with controls, respectively. However, T-SH and vitamin E levels were 27% and 44% higher in lung cancer patients, respectively. Results show that the overproduction of reactive species in patients with lung cancer may be interfering with the activity of δ-ALA-D. Likewise, the decrease in the activity of this enzyme may be contributing for the oxidative stress.
Le texte complet de cet article est disponible en PDF.Keywords : Lung cancer, δ-Aminolevulinate dehydratase, Oxidative stress, Antioxidants
Plan
Vol 68 - N° 5
P. 603-609 - juin 2014 Retour au numéro
Article précédent
- Humanized anti-VEGFR-2 ScFv-As2O3-stealth nanoparticles, an antibody conjugate with potent and selective anti-hepatocellular carcinoma activity
- Yin Xiangbao, Wu Linquan, Huang Mingwen, Zhou Fan, Wang Kai, Yu Xin, Wang Kaiyang, Fu Huaqun
- Inhibition of phosphoinositide 3-kinase is associated with reduced angiogenesis and an altered expression of angiogenic markers in endothelioma cells
- P. Mabeta
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?