Estimated prevalence of chronic Q fever among Coxiella burnetii seropositive patients with an abdominal aortic/iliac aneurysm or aorto-iliac reconstruction after a large Dutch Q fever outbreak - 29/06/14
, Peter C. Wever b, André S. van Petersen c, Peter J. Lestrade d, Monique G.L. de Jager-Leclercq e, Mirjam H.A. Hermans f, Frans L. Moll g, Olivier H.J. Koning a, Nicole H.M. Renders bSummary |
Objectives |
The aim of this study was to estimate the seroprevalence of Q fever and prevalence of chronic Q fever in patients with abdominal aortic and/or iliac disease after the Q fever outbreak of 2007–2010 in the Netherlands.
Methods |
In November 2009, an ongoing screening program for Q fever was initiated. Patients with abdominal aortic and/or iliac disease were screened for presence of IgM and IgG antibodies to phase I and II antigens of Coxiella burnetii using immunofluorescence assay and presence of C. burnetii DNA in sera and/or vascular wall tissue using polymerase chain reaction (PCR).
Results |
A total of 770 patients with abdominal aortic and/or iliac disease were screened. Antibodies against C. burnetii were detected in 130 patients (16.9%), of which 40 (30.8%) patients showed a serological profile of chronic Q fever. Three patients presented with acute Q fever, one of which developed to chronic Q fever over time. The number of aneurysm-related acute complications in patients with chronic Q fever was significantly higher compared to patients negative for Q fever (p = 0.013); 9.0% (30/333) vs. 30.0% (6/20). Eight out of 46 patients with past resolved Q fever (8/46, 17.4%) presented with aneurysm-related acute complications (no significant difference).
Conclusion |
The prevalence of chronic Q fever in C. burnetii seropositive patients with abdominal aortic and/or iliac disease living in an epidemic area in the Netherlands is remarkably high (30.8%). Patients with an aneurysm and chronic Q fever present more often with an aneurysm-related acute complication compared to patients without evidence of Q fever infection.
Le texte complet de cet article est disponible en PDF.Keywords : Chronic Q fever, Aneurysm, Vascular graft, Seroprevalence
Plan
| ☆ | Presented to the Annual Meeting of the Dutch Society of Surgery, Veldhoven, The Netherlands, November 2011. |
| ☆☆ | Presented to the Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, United States of America, September 2011. |
Vol 69 - N° 2
P. 154-160 - août 2014 Retour au numéro
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