A practical approach to the child with abnormal liver tests - 17/06/14

Doi : 10.1016/j.clinre.2014.02.010

Thierry Lamireau ^a,^⁎ , Valérie McLin ^b, Valério Nobili ^c, Pietro Vajro ^d
^a Pediatric Gastroenterology Unit, Children's Hospital, place Amélie-Raba-Léon, 33076 Bordeaux, France
^b Pediatric Gastroenterology Unit and Swiss Center for Liver Disease in Children, University Hospitals Geneva, 6, rue Willy Donze, 1211 Geneva 14, Switzerland
^c Hepatometabolic Unit, Bambino Gesu’ Children Hospital, IRCCS, Rome, Italy
^d Department of Medicine and Surgery, Pediatric Section, University of Salerno, 84081 Baronissi (SA), Italy

^⁎Corresponding author. Tel.: +33 5 56 79 98 24; fax: +33 5 56 79 56 58.

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Summary

The presence of elevated aminotransferases on routine blood tests can reveal liver diseases of various severities. In children, etiologies are more numerous and complex than those usually considered in adults. Information derived from family and personal history, physical examination and basic laboratory data are necessary to reach a timely and correct diagnosis. A stepwise approach is proposed to guide the timing of more specific investigations that are often required.

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