Trends in surgical results of hepatic resection for hepatocellular carcinoma: 1,000 consecutive cases over 20 years in a single institution - 30/05/14
, Eiji Tsuijita, M.D., Ph.D. a, Kazuki Takeishi, M.D. a, Teruyoshi Ishida, M.D., Ph.D. b, Toru Ikegami, M.D., Ph.D. b, Takuhiro Ezaki, M.D., Ph.D. b, Takashi Maeda, M.D., Ph.D. a, Tohru Utsunomiya, M.D., Ph.D. a, Naofumi Nagasue, M.D., Ph.D. b, Ken Shirabe, M.D., Ph.D. b, Yoshihiko Maehara, M.D., Ph.D. bAbstract |
Background |
Surgical results have been reported to be improved in hepatic resections for hepatocellular carcinoma (HCC) in recent years, but the detailed trends in surgical results for HCC in a single high-volume center are still not clear.
Methods |
Surgical results in 1,000 hepatic resections for HCC performed at a single medical center from 1989 to 2011 were analyzed. Patients were divided into 3 groups: those performed in the early period (1989 to 1995, n = 181), the middle period (1996 to 2004, n = 391), and the late period (2005 to 2011, n = 428).
Results |
Hospital mortality (3.9%, 1.0%, and .5%; P = .0027) and morbidity (45%, 24%, and 15%; P < .0001) rates were significantly decreased. The overall survival rates were significantly improved (50%, 72%, and 78% at 5 years; P = .0021), but there was no significant difference in the disease-free survival (29%, 34%, and 31% at 5 years; P = .7823).
Conclusions |
Surgical results of hepatic resections for HCC were significantly improved, with the mortality rate nearly reaching 0%. The 5-year survival rate after hepatic resections for HCC was also improved to 78%, but the consistently high rate of HCC recurrence after hepatic remains a problem.
Le texte complet de cet article est disponible en PDF.Keywords : 5-year disease-free survival, 5-year survival, Hepatocellular carcinoma, Hepatic resection, Morbidity and mortality
Plan
| The authors declare no conflict of interest. |
Vol 207 - N° 6
P. 890-896 - juin 2014 Retour au numéro
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