Association of IL-2RA and IL-2RB genes with erosive status in early rheumatoid arthritis patients (ESPOIR and RMP cohorts) - 24/05/14
, Cedric Lukas d, Delphine Nigon c, Karen Dawidowicz e, Jacques Morel d, Jean Sibilia f, Bénédicte Jamard c, Anne Cambon-Thomsen a, b, Alain Cantagrel b, c, g, Philippe Dieudé e, h, i, Arnaud Constantin a, b, cBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 3 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objectives |
To assess the impact of single nucleotide polymorphisms (SNPs) in IL-2RA (rs2104286) and IL-2RB (rs743777 and rs3218253) genes on the risk of erosions in rheumatoid arthritis (RA) patients.
Methods |
This work is derived from 2 prospective cohorts of early RA: ESPOIR (n=439) and RMP (n=180). The proportions of patients with erosions at baseline and 1year according to the genotypes of IL2RA (rs2104286) or the haplotypes constructed with the 2 SNPs of IL2RB were compared in the whole population and in ACPA positive patients. A meta-analysis assessing the risk of erosion depending on the haplotypes of the 2 SNPs of IL-2RB was performed using the Mantel-Haenszel method. A multivariate model was used to assess the independent effect of the haplotypes of IL-2RB on the risk of erosions.
Results |
The AC haplotype of IL-2RB carriage was significantly associated with the rate of erosions in ACPA positive patients in ESPOIR cohort (rate of erosions: AC/AC: 78% versus GC or GT/GC or GT: 44%, p=0.001). A meta-analysis of ESPOIR and RMP cohorts confirmed that the carriage of AC haplotype was significantly associated with the rate of erosions at 1year in the whole sample (OR[95%CI]=1.92[1.14–3.22], p=0.01) and in ACPA positive patients (OR[95%CI]=3.34[1.68–6.67], p=0.0006). A multivariate model in ESPOIR cohort demonstrated the independent effect of the carriage of the AC haplotype (6.03[1.94–18.69], p=0.002) on the risk of erosions in ACPA+ patients.
Conclusion |
A haplotype constructed with 2 SNPs located on IL-2RB gene was associated with erosive status in early RA.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, IL-2RA, IL-2RB, Single nucleotid polymorphism, Autoantibodies, Disease progression
Plan
Vol 81 - N° 3
P. 228-234 - mai 2014 Retour au numéro
Article précédent
- Ultrasound evaluation of synovitis in RA: Correlation with clinical disease activity and sensitivity to change in an observational cohort study
- Pascal Zufferey, Laure Brulhart, Giorgio Tamborrini, Axel Finckh, Almut Scherer, Burkhard Moller, Hans-Rudolf Ziswiler
- High pain catastrophizing scores in one-fourth of patients on biotherapy for spondylarthritis or rheumatoid arthritis
- Mélanie Penhoat, Alain Saraux, Benoît Le Goff, Peggy Augereau, Yves Maugars, Jean-Marie Berthelot
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?