A new murine model to study musculoskeletal tuberculosis (short communication) - 15/05/14
, Jurgen H. Runge c , Aart J. Nederveen c , Joris J.T.H. Roelofs d , Jaap Stoker c , Mario Maas c , Tom van der Poll a, b, e Summary |
Musculoskeletal tuberculosis (TB) is a severe extrapulmonary manifestation of chronic Mycobacterium (M.) tuberculosis infection. Considering increasing incidence, multi-drug resistance and associated treatment difficulties, more preclinical research is needed. In this study we developed a murine model for musculoskeletal TB. Mice, intranasally infected with M. tuberculosis, were sacrificed after ten months. Mycobacterial growth was detected in lung and femur homogenates. Ziehl–Neelsen staining of paraffin-embedded femurs showed acid-fast rods in the myelum and Magnetic Resonance Imaging demonstrated osteomyelitis and macronodular tuberculomas. This new murine model of musculoskeletal TB might be of value to further investigate immunologic and radiologic responses.
Le texte complet de cet article est disponible en PDF.Keywords : Bone and joint tuberculosis, Spinal tuberculosis, Pott's disease, Magnetic resonance imaging, Musculoskeletal imaging, Mice
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Vol 94 - N° 3
P. 306-310 - mai 2014 Retour au numéro
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