Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms - 15/05/14

Doi : 10.1016/j.tube.2014.02.002

Yi Jiang ^a,^b,^{^{1
Yi Jiang, Li Wan, Zhijian Zhang and Haican Liu contributed equally to this study.}} , Li Wan ^a,^b,^{^{1
Yi Jiang, Li Wan, Zhijian Zhang and Haican Liu contributed equally to this study.}}, Zhijian Zhang ^c,^{^{1
Yi Jiang, Li Wan, Zhijian Zhang and Haican Liu contributed equally to this study.}}, Haican Liu ^a,^b,^{^{1
Yi Jiang, Li Wan, Zhijian Zhang and Haican Liu contributed equally to this study.}}, Hui Pang ^d, Wen Zhang ^a,^b, Xiuqin Zhao ^a,^b, Haiyin Wang ^a,^b, Guilian Li ^a,^b, Chen Chen ^a,^b, Biao Kan ^a,^b,^⁎ , Kanglin Wan ^a,^b,^⁎
^a National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China
^b Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China
^c Respiratory Diseases Department of Nanlou, Chinese People's Liberation Army General Hospital, 28# Fuxing Road, Haidian District, Beijing 100853, China
^d Immunology Department, Changzhi Medical College, Shanxi, China

^∗Corresponding author. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O. Box 5, Changping, Beijing 102206, China. Tel./fax: +86 10 58900779.^∗∗Corresponding author. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O. Box 5, Changping, Beijing 102206, China. Tel./fax: +86 10 58900703.

Summary

Host immune pressure and associated parasite immune evasion are key features of host-pathogen co-evolution. A previous study showed that human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved and thus it was deduced that M. tuberculosis lacks antigenic variation and immune evasion. Here, we selected 162 clinical M. tuberculosis complex (MTBC) isolates from China, amplified gene encoding Rv3878 and compared the sequences. The results showed that Rv3878, a conserved hypothetical alanine rich protein, is not conserved in M. tuberculosis strains and there are polymorphisms existing in the protein. The large number of amino acid changes in its T cell epitopes may reflect ongoing immune evasion.

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Keywords : Rv3878, Mycobacterium tuberculosis, Immune evasion

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Introduction

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Strains and DNA preparation

Mutation, insertion and deletion in gene sequences

Changes in protein level

Changes in T cell epitopes

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Vol 94 - N° 3

P. 245-251 - mai 2014 Retour au numéro

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Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms - 15/05/14

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