Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries - 08/05/14
, Margot R. Krauss b, Karen Megazzini b, Conrado Milani Coutinho c, Regis Kreitchmann d, Victor Hugo Melo e, José Henrique Pilotto f, Mariana Ceriotto g, Cristina B. Hofer a, George K. Siberry h, D. Heather Watts hfor the
NICHD International Site Development Initiative (NISDI) Pediatric Protocol
Summary |
Objectives |
To evaluate the incidence of and risk factors for hypertensive disorders in a cohort of HIV-infected pregnant women.
Methods |
Hypertensive disorders (HD) including preeclampsia/eclampsia (PE/E) and pregnancy induced hypertension, and risk factors were evaluated in a cohort of HIV-infected pregnant women from Latin America and the Caribbean enrolled between 2002 and 2009. Only pregnant women enrolled for the first time in the study and delivered at ≥20 weeks gestation were analyzed.
Results |
HD were diagnosed in 73 (4.8%, 95% CI: 3.8%–6.0%) of 1513 patients; 35 (47.9%) had PE/E. HD was significantly increased among women with a gestational age-adjusted body mass index (gBMI) ≥25 kg/m2 (OR = 3.1; 95% CI: 1.9–5.0), hemoglobin (Hg) ≥11 g/dL at delivery (OR = 2.1; 95% CI: 1.2–3.6) and age ≥35 years (OR = 1.8; 95% CI: 1.1–3.2). PE/E was increased among women with a gBMI ≥25 kg/m2 (OR = 3.0; 95% CI: 1.5–6.0) and Hg ≥11 g/dL at delivery (OR = 2.8; 95% CI: 1.2–6.5). A previous history of PE/E increased the risk of PE/E 6.7 fold (95% CI: 1.8–25.5). HAART before conception was associated with PE/E (OR = 2.3; 95% CI: 1.1–4.9).
Conclusions |
HIV-infected women, with a previous history of PE/E, a gBMI ≥25 kg/m2, Hg at delivery ≥11 g/dL and in use of HAART before conception are at an increased risk of developing PE/E during pregnancy.
Le texte complet de cet article est disponible en PDF.Keywords : HIV-infected women, Pregnancy, Hypertensive disorders, Preeclampsia, Eclampsia
Plan
| ☆ | The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the US National Institutes of Health or the Department of Health and Human Services. |
Vol 68 - N° 6
P. 572-580 - juin 2014 Retour au numéro
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