The changes in MUC5AC expression in gastric cancer before and after Helicobacter pylori eradication - 23/04/14
, Xin-min Qiu a , Xing-jun Yan b Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 2 |
| Vidéos | 0 |
| Autres | 0 |
Summary |
Purpose |
To investigate MUC5AC expression in gastric cancer before and after Hp eradication.
Methods |
The MUC5AC protein and mRNA were detected in gastric cancer tissue by western blot and real time PCR protocols before and after Hp eradication (Hp positive group). Gastric cancer tissue without Hp infection served as the control group (Hp negative group).
Results |
The MUC5AC protein and mRNA expression was more significantly increased in gastric cancer after Hp eradication as compared to that before Hp eradication, but it was significantly lower than of the control group. The relative amount of MUC5AC in the well-differentiated cancer was higher than that of the moderately or poorly-differentiated cancer, in either Hp positive or control groups. The relative amount of MUC5AC in cancer tissues with more than five metastatic lymph nodes was significantly lower than that of the cancer tissues with five or less metastatic lymph nodes, and was significantly lower in the Hp positive group as compared to that of the control group.
Conclusions |
The reduction of the MUC5AC might be related to gastric carcinogenesis caused by Hp and the progression of gastric cancer.
Le texte complet de cet article est disponible en PDF.Plan
Vol 38 - N° 2
P. 235-240 - avril 2014 Retour au numéro
Article précédent
- XRCC3 Thr241Met polymorphism and gastric cancer susceptibility: A meta-analysis
- Xian-Peng Qin, Yong Zhou, Yi Chen, Ning-Ning Li, Xiao-Ting Wu
- Sustained response with gemcitabine plus Nab-paclitaxel after folfirinox failure in metastatic pancreatic cancer: Report of an effective new strategy
- Alix Portal, Simon Pernot, Nathalie Siauve, Bruno Landi, Céline Lepère, Orianne Colussi, Philippe Rougier, Aziz Zaanan, Benjamin Verrière, Julien Taieb
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?