Age-dependent Association Between Dickkopf-1 and Calcium-containing Urolithiasis - 22/04/14
Abstract |
Objective |
To evaluate the serum Dickkopf-1 (DKK1) level in patients with calcium-containing upper urinary tract stones (Ca-UUTS).
Methods |
The study retrospectively enrolled 184 patients with Ca-UUTS and 46 age-matched controls. The serum DKK1 level and urine calcium/creatinine ratio were detected in both groups.
Results |
The mean serum DKK1 level in the controls was 321.7 ± 284.1 pg/mL, which was significantly lower than that of the patients with calcium oxalate and calcium phosphate (CaOx + CaP), CaOx, and CaP stones (687.8 ± 600.2, 640.5 ± 721.5, and 857.9 ± 913.2 pg/mL, respectively). The mean urine calcium/creatinine ratio, an indicator of hypercalciuria, was higher in the Ca-UUTS patients with CaOx + CaP (0.10 ± 0.06), CaOx (0.13 ± 0.07), and CaP (0.12 ± 0.07) stones than in the controls (0.08 ± 0.04). Statistical significance was noted only in the patients with CaOx (P = .005) and CaP (P = .037) stones. A significant positive association was found between the serum DKK1 level and age in the control group but not in the Ca-UUTS patients. In subjects aged younger than 50 years, the serum DKK1 level in the Ca-UUTS group was significantly higher than in the control group (605.3 ± 514.4 vs 274 ± 229.8 pg/mL, P = .0003). The serum DKK1 level was not associated with stone size.
Conclusion |
Serum DKK1, an inhibitor of the Wnt signaling pathway, was positively associated with the formation of Ca-UUTS, especially in patients aged younger than 50 years.
Le texte complet de cet article est disponible en PDF.Plan
| Yeong-Chin Jou and Yuh-Shyan Tsai contributed equally. |
|
| Financial Disclosure: The authors declare that they have no relevant financial interests. |
|
| Funding Support: This study was supported by the Chia-Yi Christian Hospital (Grant R101-16). |
Vol 83 - N° 5
P. 1006-1010 - mai 2014 Retour au numéro
Article précédent
- Decreasing Cost of Flexible Ureterorenoscopy: Single-use Laser Fiber Cost Analysis
- R.A. Chapman, B.K. Somani, A. Robertson, S. Healy, S.G. Kata
- Long-term Functional Outcome of Percutaneous Nephrolithotomy in Solitary Kidney
- Nasr A. El-Tabey, Ahmed R. El-Nahas, Ibrahim Eraky, Ahmed M. Shoma, Ahmed M. El-Assmy, Shady A. Soliman, Ahmed A. Shokeir, Tarek Mohsen, Hamdy A. El-Kappany, Mahmoud R. El-Kenawy
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?