Lack of efficacy with 1064-nm neodymium:yttrium-aluminum-garnet laser for the treatment of onychomycosis: A randomized, controlled trial - 16/04/14
Abstract |
Background |
Laser therapies have been Food and Drug Administration approved for temporary nail plate clearance; however, there is minimal evidence of their long-term efficacy.
Objective |
We sought to evaluate the clinical and mycological clearance of toenails treated with 1064-nm neodymium:yttrium-aluminum-garnet laser versus no treatment.
Methods |
This was a randomized, controlled, single-center trial comparing 2 treatments with 1064-nm neodymium:yttrium-aluminum-garnet laser (fluence of 5 J/cm2, rate of 6 Hz) spaced 2 weeks apart versus no treatment in 27 patients (N = 125 affected nails) with clinical and mycological diagnosis of onychomycosis. At 3 months, patients were assessed with mycological cultures and proximal nail plate measurements. Patients treated with laser were also assessed with proximal nail plate measurements at 12 months.
Results |
At 3 months, 33% of patients treated with laser achieved a negative mycological culture compared with 20% of the control group (P = .49), and had more proximal nail plate clearance compared with control subjects (0.44 vs 0.15 mm, P = .18), which was not statistically significant. At 12 months, there was no difference in nail plate clearance between laser versus control subjects (0.24 vs 0.15 mm, P = .59).
Limitations |
Our study was limited by the small sample size and number of treatments.
Conclusions |
There was no significant mycological culture or clinical nail plate clearance with 1064-nm neodymium:yttrium-aluminum-garnet laser compared with control.
Le texte complet de cet article est disponible en PDF.Key words : 1064-nm neodymium:yttrium-aluminum-garnet laser, onychomycosis
Plan
The JOULE ClearSense handpiece was loaned to Stanford Department of Dermatology from Sciton Inc for the purposes of the study. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 70 - N° 5
P. 911-917 - mai 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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