Characteristics of noninvoluting congenital hemangioma: A retrospective review - 16/04/14
Abstract |
Background |
Noninvoluting congenital hemangioma (NICH) is a distinct vascular tumor of infancy.
Objective |
We describe the clinical characteristics, histopathology, imaging, and natural history of NICH and compare our findings with previous reports.
Methods |
We conducted a retrospective review of charts and photographic databases from 2 vascular anomaly centers over a 15-year period.
Results |
Thirty cases of NICH were identified. All patients had fully formed vascular lesions at birth that demonstrated a nonprogressive course. The trunk and lower extremities were preferred sites and there was a female predominance. Thirteen of 30 patients reported pain. Focal necrosis and scarring was seen in a minority. Doppler studies, when performed, confirmed high vascular flow. Microscopic evaluation of 4 excised lesions showed lobular areas of endothelial cell proliferation directly adjacent to ectatic malformed vessels. Immunohistochemical studies demonstrated absence of glucose transporter-1 protein expression in every case. Wilms tumor–1 positivity was observed in lobular areas. The larger vessels did not stain with Wilms tumor–1, but some displayed D2-40 positivity.
Limitations |
Patients were referred to university-based pediatric vascular anomaly centers, with potential bias toward more severe or extensive cases.
Conclusions |
This retrospective study highlights the unique clinical and histopathologic features of NICH.
Le texte complet de cet article est disponible en PDF.Key words : infantile hemangiomas, noninvoluting congenital hemangioma, vascular tumors
Abbreviations used : Glut-1, IH, MRI, NICH, RICH, WT
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 70 - N° 5
P. 899-903 - mai 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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