High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis - 06/04/14

Doi : 10.1016/j.jinf.2013.12.012

Chun-Ta Huang ^a,^b,^c, Li-Na Lee ^d, Chao-Chi Ho ^a, Chin-Chung Shu ^a,^b,^c, Sheng-Yuan Ruan ^a, Yi-Ju Tsai ^e, Jann-Yuan Wang ^a,^⁎ , Chong-Jen Yu ^a
^a Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
^b Department of Traumatology, National Taiwan University Hospital, Taipei 100, Taiwan
^c Graduate Institute of Clinical Medicine, National Taiwan University, Taipei 100, Taiwan
^d Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
^e School of Medicine, College of Medicine, Fu-Jen Catholic University, Taipei 100, Taiwan

^∗Corresponding author. Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan. Tel.: +886 2 23562905; fax: +886 2 23582867.

Summary

Objectives

Comparisons of procalcitonin (PCT), C-reactive protein (CRP), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) would expand our knowledge of which biomarker is the best predictor for outcomes of patients with pulmonary tuberculosis (PTB).

Methods

We prospectively enrolled 243 PTB patients, in whom PCT, CRP, and sTREM-1 measurement were performed to evaluate their prognostic value for 6-month mortality.

Results

Serum PCT, CRP, and sTREM-1 levels on diagnosis of PTB were significantly higher in nonsurvivors (2.22 ± 6.22 vs. 0.13 ± 0.31 ng/mL, P = 0.043; 42.1 ± 59.4 vs. 12.5 ± 29.1 mg/L, P = 0.004; 332 ± 362 vs. 128 ± 98 pg/mL, P = 0.001, respectively) as compared with 6-month survivors. In multivariate Cox regression analysis, PCT ≧0.5 ng/mL (hazard ratio 4.13, 95% CI, 1.99–8.58) and sTREM-1 ≧129 pg/mL (hazard ratio 3.39, 95% CI, 1.52–7.58) remained independent mortality predictors. Serum PCT and sTREM-1 levels above the cutoffs were also associated with the presence of disseminated tuberculosis.

Conclusions

Among PTB patients, higher PCT, CRP, and sTREM-1 levels are observed in nonsurvivors than in 6-month survivors. Serum levels of PCT and sTREM-1 over the cutoffs are independently associated with a poor outcome. In addition, higher PCT and sTREM-1 levels would raise the clinical suspicion of disseminated tuberculosis.

Le texte complet de cet article est disponible en PDF.

Keywords : Biomarker, C-reactive protein, Procalcitonin, Prognosis, Triggering receptor expressed on myeloid cells-1, Tuberculosis

Plan

Introduction

Materials and methods

Study population

Blood sampling and measurement of PCT, CRP, and sTREM-1

Serum PCT, CRP, and sTREM-1 levels

Predictive value of PCT, CRP, and sTREM-1 for 6-month mortality

Discussion

☆	This is an open access article under the CC BY-NC-ND license (3.0/).

Export

Vol 68 - N° 5

P. 440-447 - mai 2014 Retour au numéro

Article précédent

Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: The effect of clonal complex
Ruth R. Miller, A. Sarah Walker, Heather Godwin, Rowena Fung, Antonina Votintseva, Rory Bowden, David Mant, Timothy E.A. Peto, Derrick W. Crook, Kyle Knox

| Article suivant

Yield of tuberculosis contact investigation in a low-incidence country
Alberto Borraccino, Enrica Migliore, Pavilio Piccioni, Iacopo Baussano, Aurelia Carosso, Massimiliano Bugiani

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis - 06/04/14

Summary

Objectives

Methods

Results

Conclusions

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL