Objective: To present two cases with Mallory-Weiss(MW) lessions complicating upper gastrointestinal endoscopies (UGE),to discuss the managment with hemoclips and to evaluate the incidence of this rare condition in our department comparing to the incidence in the litterature since the first report of iatrogenic MW by Watts in 1976(Gastrointest Endsc 1976;22:171- 2). Methods:We review retrospectively the data of 6161 upper gastrointestinal endoscopies, both diagnostic and therapeutic, performed in a 5 years period (5/1994-5/1999) in our department. Results:Two cases of MW syndrome occured during UGE (0.03%). A woman (A) aged 70 underwent UGE for anaemia and a man (B) aged 63 underwent UGE for dyspeptic symptoms, both without receiving i.v. sedation but only pharyngeal anaesthesia. Both showed intollerance (nausea, retching and struggling) during procedure a condition that predisponse to develope iatrogenic MW syndrome. None of the patient had hiatus hernias which also predisponse to this complication according to the litterature. MW tears with actively bleeding were seen at the gastroesophageal junction by retroflexion of the endoscope. Subject A had a tear of 1.5 cm length whereas B had a tear of 4cm. Immediate hemostasis with hemoclips (Olympus MD-850)was performed (4 clips to A and 2 to B patient) for stopping the bleeding. No rebleeding was noted and no blood transfusion was necessary. Discussion:According to our experience Mallory-Weiss syndrome occuring during upper gastrointestinal endoscopy is extremely rare (0.03%) similar to previously published (0.00-0.49%). Endoscopic hemostasis with hemoclips is an effective method to control bleeding in these cases where the lession is linear and the application is easy.