Autosomal dominant inheritance of central centrifugal cicatricial alopecia in black South Africans - 14/03/14
Abstract |
Background |
Central centrifugal cicatricial alopecia (CCCA) is the commonest type of primary scarring alopecia in women of African descent. Little is currently known about the disease genetics.
Objective |
We sought to investigate patterns of inheritance in CCCA and ascertain the contribution of nongenetic factors such as hair-grooming habits to the pathogenesis of the disease.
Methods |
Affected individuals with at least 1 available family member were recruited from 2005 through 2012 inclusive for pedigree analysis. CCCA was diagnosed on clinical and histopathological grounds.
Results |
Fourteen index African families with 31 immediate family members participated in the initial screening. The female to male ratio was 29:2 with an average age of 50.4 years. All patients displayed histologic features typical for CCCA. Pedigree analysis suggested an autosomal dominant mode of inheritance. Hair-grooming habits were found to markedly influence disease expression.
Limitations |
Small number of patients is a limitation.
Conclusion |
CCCA can be inherited in an autosomal dominant fashion, with partial penetrance and a strong modifying effect of hairstyling and gender.
Le texte complet de cet article est disponible en PDF.Key words : African, black, familial, follicular degeneration syndrome, genetic, hair loss, lymphocytic primary scarring alopecia, scarring alopecia, South Africa
Abbreviations used : CCCA, CHLG, DM
Plan
Dr Dlova is supported by the Discovery Foundation Academic Fellowship Award, Dermatological Society of South Africa Research Grant, University of KwaZulu-Natal (UKZN) College of Health Sciences Strategic Research Fund, UKZN Competitive Research Fund, and National Research Foundation/Indigenous Knowledge Systems, Medical Education Partnership Initiative and is the recipient of the UKZN Leadership and Equity Advancement Program. |
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Conflicts of interest: None declared. |
Vol 70 - N° 4
P. 679 - avril 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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