The Impact of Early Nutrition on Incidence of Allergic Manifestations and Common Respiratory Illnesses in Children - 07/03/14
, Deolinda M. Scalabrin, MD, PhD d
Reprint requests: Susan Hazels Mitmesser, PhD, Mead Johnson Nutrition, 2400 W Lloyd Expressway, Evansville, IN 47721.Abstract |
Objective |
To investigate the incidence of allergic and respiratory diseases through age 3 years in children fed docosahexaenoic acid (DHA)- and arachidonic acid (ARA)-supplemented formula during infancy.
Study design |
Children who completed randomized, double-blind studies of DHA/ARA-supplemented (0.32%-0.36%/0.64%-0.72% of total fatty acids, respectively) versus nonsupplemented (control) formulas, fed during the first year of life, were eligible. Blinded study nurses reviewed medical charts for upper respiratory infection (URI), wheezing, asthma, bronchiolitis, bronchitis, allergic rhinitis, allergic conjunctivitis, otitis media, sinusitis, atopic dermatitis (AD), and urticaria.
Results |
From the 2 original cohorts, 89/179 children participated; 38/89 were fed DHA/ARA formula. The DHA/ARA group had significantly lower odds for developing URI (odds ratio [OR], 0.22; 95% confidence interval [CI], 0.08-0.58), wheezing/asthma (OR, 0.32; 95% CI, 0.11-0.97), wheezing/asthma/AD (OR, 0.25; 95% CI, 0.09-0.67), or any allergy (OR, 0.28; 95% CI, 0.10-0.72). The control group had significantly shorter time to first diagnosis of URI (P = .006), wheezing/asthma (P = .03), or any allergy (P = .006).
Conclusions |
DHA/ARA supplementation was associated with delayed onset and reduced incidence of URIs and common allergic diseases up to 3 years of age.
Le texte complet de cet article est disponible en PDF.Mots-clés : AD, ARA, CI, DHA, FA, HR, LCPUFA, OM, OR, RAD, URI
Plan
| Supported by Mead Johnson Nutrition. The original randomized trials of the 2 cohorts were funded by the National Institutes of Health, grant number HD22380. E.B. was responsible for the design and conduct of the 2 cohorts. All authors were involved in the design, conduct, and interpretation of this study, and all critically reviewed and approved the manuscript. S.M. wrote the first draft of the manuscript. C.B., C.H., S.M., and D.S. are employees of Mead Johnson Nutrition. |
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| Registration with clinicaltrials.gov: NCT00740974. |
Vol 156 - N° 6
P. 902 - juin 2010 Retour au numéro
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