Booster Vaccination After Neonatal Priming with Acellular Pertussis Vaccine - 07/03/14
Doi : 10.1016/j.jpeds.2009.12.019
Markus Knuf, MD a, ⁎ 
, Heinz-Josef Schmitt, MD a, Jeanne-Marie Jacquet, PhD b, Alix Collard, PhD b, Dorothee Kieninger, MD a, Claudius U. Meyer, PhD a, Claire-Anne Siegrist, MD c, Fred Zepp, MD a
, Heinz-Josef Schmitt, MD a, Jeanne-Marie Jacquet, PhD b, Alix Collard, PhD b, Dorothee Kieninger, MD a, Claudius U. Meyer, PhD a, Claire-Anne Siegrist, MD c, Fred Zepp, MD a a Department of Pediatrics, Johannes Gutenberg-University, Mainz, Germany
b GlaxoSmithKline Biologicals, Rixensart, Belgium
c Center for Vaccinology and Neonatal Immunology, University of Geneva, Switzerland
Reprint requests: Dr Markus Knuf, Zentrum für Kinder-und Jugendmedizin, Johannes Gutenberg-Universität, Langenbeckstraße 1, D-55131 Mainz, Germany.Abstract |
After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.
Le texte complet de cet article est disponible en PDF.Mots-clés : aP, DT, FHA, GMC, GMT, HBs, HBP, Hib, IPV, PRP
Plan
| Funded by GlaxoSmithKline Biologicals, Rixensart, Belgium (Study No. 105752). J.-M.J. and A.C. are employees of GlaxoSmithKline Biologicals. C.-A.S., H.-J.S., F.Z., and M.K. have received honoraria for participation to scientific advisory boards of GSK and other pharmaceutical companies, as well as research grants from pharmaceutical companies within the past 3 years. |
|
| D.K. and C.U.M. declare no conflicts of interest. |
|
| Registered at www.clinicaltrials.com (NCT00289796). |
© 2010
Mosby, Inc. Tous droits réservés.
Vol 156 - N° 4
P. 675-678 - avril 2010 Retour au numéro
Article précédent
- A Young Girl with Weather-Beaten, Waxy Knuckles
- Nina C. Botto, Rebecca L. Shpall, Jinah Kim, Anna L. Bruckner
- Bifidobacterium Septicemia Associated with Postoperative Probiotic Therapy in a Neonate with Omphalocele
- Akira Ohishi, Shigehiro Takahashi, Yushi Ito, Yoshihisa Ohishi, Keiko Tsukamoto, Yukiko Nanba, Naoki Ito, Satsuki Kakiuchi, Akihiko Saitoh, Masami Morotomi, Tomoo Nakamura
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?