Failure of Resolution of Portal Fibrosis during Omega-3 Fatty Acid Lipid Emulsion Therapy in Two Patients with Irreversible Intestinal Failure - 07/03/14
Doi : 10.1016/j.jpeds.2009.08.033
Jason S. Soden, MD a, ⁎ 
, Mark A. Lovell b, Kristin Brown a, David A. Partrick c, Ronald J. Sokol a, c
, Mark A. Lovell b, Kristin Brown a, David A. Partrick c, Ronald J. Sokol a, c a Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine and The Children’s Hospital, Aurora, CO
b Department of Pathology, Department of Pediatric Surgery, University of Colorado Denver School of Medicine and The Children’s Hospital, Aurora, CO
c Clinical Translational Research Center, University of Colorado Denver School of Medicine and The Children’s Hospital, Aurora, CO
Reprint requests: Jason S. Soden, MD, Assistant Professor of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital, 13123 E 16th Ave, Box B290, Aurora, CO 80045.Abstract |
Parenteral omega-3 fatty acid lipid emulsions have been evaluated for their potential role in reversing intestinal failure-associated liver disease. We report our experience using Omegaven in 2 patients with irreversible intestinal failure and intestinal failure-associated liver disease. Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy.
Le texte complet de cet article est disponible en PDF.Mots-clés : HD, IFALD, LITx, MVID, PN
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Vol 156 - N° 2
P. 327-331 - février 2010 Retour au numéro
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