Long-term Clinical Significance of Thyroid Autoimmunity in Children with Celiac Disease - 07/03/14
, Giampaolo Ricci, MD, Federico Baronio, MD, Angela Miniaci, MD, Milva Bal, MD, Barbara Bigucci, MD, Veronica Conti, MD, Alessandro Cicognani, MD
Reprint requests: Dr Alessandra Cassio, Department of Pediatrics, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy.Abstract |
Objective |
To evaluate the long-term outcome of thyroid function and autoimmunity in a large series of children with celiac disease.
Study design |
This longitudinal, retrospective study (duration of follow-up, 8.9 ± 4.0 years) was conducted at the Pediatric Department, University of Bologna, Italy. One hundred thirty-five consecutive patients diagnosed between June 1990 and December 2004 and followed on a gluten-free diet were examined. Inclusion criteria were good dietary compliance and duration of follow-up for at least 3 years.
Results |
Of 101 patients who never showed positive antithyroid titers during the follow-up, 86 remained euthyroid; 15 showed high thyroid-stimulating hormone values at diagnosis that normalized in 11 cases after 12 to 18 months of gluten withdrawal. Of 31 patients with persistently positive antibody titers, 23 (74%) remained consistently euthyroid during the follow-up and 8 (26%) had a subclinical hypothyroidism. The prevalence of cases with positive antibodies was similar in children with growth retardation or gastroenterological symptoms at diagnosis and different durations of gluten exposure.
Conclusions |
The presence of antithyroid antibodies in children with celiac disease has a low predictive value for the development of thyroid hypofunction during the indicated surveillance period. Longer follow-up is needed.
Le texte complet de cet article est disponible en PDF.Mots-clés : Ab anti-TPO, Ab anti-Tg, CD, GFD, TSH
Plan
| The authors declare no conflicts, real or perceived. |
Vol 156 - N° 2
P. 292-295 - février 2010 Retour au numéro
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