Variation in the Prevalence of Congenital Heart Defects by Maternal Race/Ethnicity and Infant Sex - 07/03/14
, Tao Wang, PhD a, Melissa L. Loscalzo, MD b, Jason L. Salemi, MPH a, c
Reprint requests: Wendy Nembhard, PhD, Department of Epidemiology & Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd, MDC 56, Tampa, FL 33612-3805.Abstract |
Objective |
To determine the prevalence of major congenital heart defects (CHD) by ethnicity and sex.
Study design |
Data from the Florida Birth Defects Registry was used to conduct a retrospective cohort study with 8029 singleton infants with 11 CHDs born 1998–2003 to resident non-Hispanic (NH) white, NH-black, and Hispanic women aged 15 to 49. Defect-specific prevalence rates, ratios, and 95% confidence intervals were calculated. Poisson regression was used to calculate adjusted ethnic-specific rate ratios (RR) for each CHD. Statistical significance was P < .0001.
Results |
Compared with NH-whites, NH-black males had significantly increased rates of pulmonary valve atresia/stenosis (RR = 1.66) but lower prevalence of aortic valve atresia/stenosis (RR = 0.33) and ventricular septal defect (VSD; RR = 0.78). Hispanic males had lower rates of aortic valve atresia/stenosis (RR = 0.28), coarctation of the aorta (RR = 0.61) and VSD (RR = 0.79). NH-black females had statistically significantly lower rates of VSD (RR = 0.75), and Hispanic females had lower rates of tetralogy of Fallot (RR = 0.54), VSD (RR = 0.84) and atrioventricular septal defects (RR = 0.53) compared with NH-whites.
Conclusions |
We found differences in ethnic susceptibilities to CHD by sex, but the cause remains unclear.
Le texte complet de cet article est disponible en PDF.Mots-clés : CHD, CMS, FBDR, ICD-9-CM, NH, PR, RVOTO, VSD
Plan
| Funded in part by the Florida Department of Health, Florida Birth Defects Registry. The authors declare no conflicts of interest. |
Vol 156 - N° 2
P. 259-264 - février 2010 Retour au numéro
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