Maternal Smoking during Pregnancy and Regional Brain Volumes in Preterm Infants - 07/03/14
, Jyrki Korkeila, MD, PhD d, f, Riitta Parkkola, MD, PhD b, e, Helena Lapinleimu, MD, PhD a, Leena Haataja, MD, PhD c, Liisa Lehtonen, MD, PhD aThe PIPARI Study Group
Reprint requests: Mikael Ekblad, BM, Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.Abstract |
Objective |
To evaluate the association between maternal smoking during pregnancy and both brain volumes and head circumference in very-low-birth-weight/very-low-gestational-age infants.
Study design |
The PIPARI Study is a prospective follow-up study of infants with a birth weight ≤1500 g or a gestational age <32 weeks born in 2001 to 2006 (n = 232) at Turku University Hospital. The brain was imaged by serial brain ultrasound examinations until discharge and magnetic resonance imaging at term age. The head circumference was measured at birth, term, and 2 years corrected age. These measures were correlated to maternal smoking during pregnancy as reported by the mothers.
Results |
The prevalence of maternal smoking was 18%. The frontal lobe (P = .01) and the cerebellar (P = .03) volumes were significantly smaller in the exposed than in the unexposed infants. The volumes of the other parts of the brain did not differ. There was no association between prenatal smoking exposure and head growth or structural brain disease.
Conclusions |
Prenatal smoking exposure was associated with significantly smaller frontal lobe and cerebellar volumes in the brains of preterm infants. This is consistent with reports showing an association between prenatal smoking exposure and impairments in frontal lobe and cerebellar functions such as emotion, impulse control, and attention.
Le texte complet de cet article est disponible en PDF.Mots-clés : ADHD, ICC, IVH, MRI, VLBW, VLGA
Plan
| Funded by the Emil Aaltonen’s Foundation, the Finnish Academy of Science, the South-West Finnish Fund of Neonatal Research, the Päivikki and Sakari Sohlberg Foundation, the Finnish Foundation for Alcohol Studies, and the Turku University Hospital Research Foundation. The funding sources had no role in study design, the collection, analysis, or interpretation of data, the writing of the article, or the decision to submit it for publication. The authors declare no conflicts of interest. |
Vol 156 - N° 2
P. 185 - février 2010 Retour au numéro
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