Do Red Cell Transfusions Increase the Risk of Necrotizing Enterocolitis in Premature Infants? - 07/03/14
Abstract |
Objective |
To test the hypothesis that red blood cell (RBC) transfusions increase the risk of necrotizing enterocolitis (NEC) in premature infants, we investigated whether the risk of “transfusion-associated” NEC is higher in infants with lower hematocrits and advanced postnatal age.
Study design |
Retrospective comparison of NEC patients and control patients born at <34 weeks gestation.
Results |
The frequency of RBC transfusions was similar in NEC patients (47/93, 51%) and control patients (52/91, 58%). Late-onset NEC (>4 weeks of age) was more frequently associated with a history of transfusion(s) than early-onset NEC (adjusted OR, 6.7; 95% CI, 1.5 to 31.2; P = .02). Compared with nontransfused patients, RBC-transfused patients were born at earlier gestational ages, had greater intensive care needs (including at the time of onset of NEC), and longer hospital stay. A history of RBC transfusions within 48-hours before NEC onset was noted in 38% of patients, most of whom were extremely low birth weight infants.
Conclusions |
In most patients, RBC transfusions were temporally unrelated to NEC and may be merely a marker of overall severity of illness. However, the relationship between RBC transfusions and NEC requires further evaluation in extremely low birth weight infants using a prospective cohort design.
Le texte complet de cet article est disponible en PDF.Mots-clés : IVH, NEC, NICU, OR, PDA, RBC, VLBW
Plan
Supported in part by NIH awards HL088922, HL086773 (C.J.), HD059142, HD043397, and a research grant by the CACA Jones Family Foundation (A.M.). The authors declare no conflicts of interest. |
Vol 157 - N° 6
P. 972 - décembre 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?