Prevalence of Iron Deficiency in Children with Down Syndrome - 07/03/14
Abstract |
Objectives |
To determine the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) in a sample of children with Down syndrome (DS) and to evaluate the effect of macrocytosis on the diagnosis of ID/IDA in these children.
Study design |
Children with DS ≥12 months of age who were followed at the Duke University Medical Center Comprehensive DS Clinic from December 2004 to March 2007 were screened for ID/IDA with a complete blood count, reticulocyte count, iron panel, and erythrocytic protoporphyrins.
Results |
A total of 114 children were enrolled, with a median age of 4.7 years. ID was identified in 12 subjects (10%), and IDA was identified in 3 subjects (3%). ID/IDA would not have been accurately diagnosed in 13 of 15 subjects (86%) if red blood cell (RBC) indices alone had been used for screening. Abnormal RBC indices with low transferrin saturation were 100% sensitive for ID/ IDA screening.
Conclusions |
Prevalence of ID/IDA in children with DS was comparable with that in the general pediatric population. Macrocytosis had implications for screening of ID/IDA with only RBC indices. We suggest ID/IDA screening in DS children be done with a laboratory panel at least including complete blood count, reticulocyte count, transferrin saturation, and serum ferritin.
Le texte complet de cet article est disponible en PDF.Mots-clés : ADHD, CBC, DS, DUMC, FEP, Hgb, ID, IDA, MCH, MCHC, MCV, NPV, PLMS, PPV, RBC, RDW, RLS, ROC, SI, TIBC, TS, ZCP
Plan
Supported by a grant from the Anna's Angels Foundation. N.D. received salary support from National Institutes of Health training grants at Duke University Medical Center (NIH-2T32CA09307 and NIH-2T32HL007057 31). B.S. received funding from (NIH 1K23HD060040-01). The authors declare no conflicts of interest. |
Vol 157 - N° 6
P. 967 - décembre 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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