A Higher Incidence of Intermittent Hypoxemic Episodes Is Associated with Severe Retinopathy of Prematurity - 07/03/14
, Jeffrey N. Bloom, MD b, Faruk Orge, MD b, Alison Schutt, MD b, Mark Schluchter, PhD c, Vinay K. Cheruvu, MSc, MS c, Michele Walsh, MD a, Neil Finer, MD d, Richard J. Martin, MD a
Reprint requests: Juliann Di Fiore, BSEE, Division of Neonatology, Rainbow Babies & Children’s Hospital Room 3100, 11100 Euclid Ave, Cleveland, OH 44106.Abstract |
Objective |
Retinopathy of prematurity (ROP), a vasoproliferative disorder of the retina in preterm infants, is associated with multiple factors, including oxygenation level. We explored whether the common intermittent hypoxemic events in preterm infants are associated with the development of ROP.
Study design |
Oxygen desaturation events were quantified in 79 preterm infants (gestational age, 24 to 27-6/7 weeks) during the first 8 weeks of life. Infants were classified as requiring laser treatment for ROP versus having less severe or no ROP. A linear mixed model was used to study the association between the incidence of intermittent hypoxia and laser treatment of ROP, controlling for gestational age, sex, race, multiple births, and initial severity of illness.
Results |
For all infants, hypoxemic events increased with postnatal age (P <.001). Controlling for all covariates, a higher incidence of oxygen desaturation events was found in the infants undergoing laser therapy for ROP (P <.001), males (P <.02), and infants of younger gestational age (P <.003).
Conclusions |
The incidence of hypoxemic events was higher in infants with ROP requiring laser therapy. Therapeutic strategies to optimize oxygenation in preterm infants should include minimization of desaturation episodes, which may in turn decrease serious morbidity in this high-risk population.
Le texte complet de cet article est disponible en PDF.Mots-clés : Fio2, LaserROP, NoLaserROP, ROP, SaO2, SNAPPE-II, VEGF
Plan
| Supported by the National Institute of Child Health and Human Development Cooperative Multicenter Neonatal Research Network (Grant HD021364-23) and the Case Western Reserve University/Cleveland Clinic (CTSA Grant UL1 RR024989) from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and the NIH Roadmap for Medical Research. The content of article is solely the responsibility of the authors and does not necessarily represent the official view of the NCRR or NIH. The authors declare no conflicts of interest. |
Vol 157 - N° 1
P. 69-73 - juillet 2010 Retour au numéro
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