Urinary Cytokines and Renal Doppler Study in Kawasaki Disease - 07/03/14
Reprint requests: Jieh-Neng Wang, MD, Department of Pediatrics, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 70421, Taiwan.Abstract |
Objective |
To investigate whether renal vasculitis is the sole cause or merely a contributing cause of renal inflammation in Kawasaki disease (KD).
Study design |
This prospective study in a university medical center in Taiwan enrolled 24 children with KD between June 2004 and November 2005. All patients underwent a technetium-99 m dimercaptosuccinic acid scintigraphy single-photon emission computed tomography scan, the results of which were used to group the patients with KD as with or without renal involvement. Urine samples underwent a cytokine analysis. Renal Doppler ultrasonography was used to evaluate renal vasculitis by measuring the pulsatility index (PI) and resistance index (RI).
Results |
Ten of the 24 patients (42%) with renal inflammatory foci were the study group; the remainder composed the control group. Urinary interleukin (IL)-6 levels were significantly higher in the study group (496.7 ± 310.9 vs 115.0 ± 65.9 ng/g urinary creatinine; P < .01), as were PI values (1.85 ± 0.70 vs 1.44 ± 0.53; P < .05). Urinary IL-6 levels and PI values were significantly (P < .05) correlated.
Conclusions |
Increased urinary IL-6 and elevated renal Doppler measures suggest that immune-mediated vasculitis is one of the mechanisms causing renal inflammation in KD.
Le texte complet de cet article est disponible en PDF.Mots-clés : Cr, DMSA, IL, IVIG, KD, PI, RI, S/D ratio, SPECT
Plan
| Part of this study was presented at the IX International Kawasaki Symposium, Taipei, Taiwan, 2008. |
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| Supported by National Cheng Kung University Hospital (Grant NCKUH-970216). The authors declare no conflicts of interest. |
Vol 156 - N° 5
P. 792-797 - mai 2010 Retour au numéro
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