Birth Weight, Family History of Diabetes, and Metabolic Syndrome in Children and Adolescents - 07/03/14
Reprint requests: Martha Rodríguez-Morán, MD, MSc, PhD, Siqueiros 225 Esq/Castañeda, 34000 Durango, Durango, Mexico.Abstract |
Objective |
To evaluate whether a coupled family history of diabetes (FHD) and low birth weight (LBW) or high birth weight (HBW) is associated with metabolic syndrome (MetS) in children and adolescents.
Study design |
A total of 1262 children and adolescents age 7-15 years were randomly selected to enroll in this cross-sectional, community-based study.
Results |
In the overall population, HBW (odds ratio [OR] = 1.4; 95% confidence interval [CI] = 1.2-10.9), but not LBW (OR = 0.97; 95% CI = 0.6-2.1), was significantly associated with MetS. In the group without FHD, HBW (OR = 1.730; 95% CI = 1.1-2.7), but not LBW (OR = 1.139; 95% CI = 0.7-23), was associated with MetS. In the group with FHD, both LBW (OR = 2.690; 95% CI = 1.4-15.1) and HBW (OR = 3.289; 95% CI = 1.3-30.6) were associated with MetS. Both LBW (OR = 4.710; 95% CI = 1.4-39.7) and HBW (OR = 3.127; 95% CI = 1.3-45.1) were associated with MetS in children and adolescents with FHD in the maternal branch but not in the paternal branch.
Conclusions |
HBW or LBW, in combination with positive FHD in the maternal branch, are determinants of MetS.
Le texte complet de cet article est disponible en PDF.Mots-clés : CI, FHD, HBW, LBW, MetS, OR
Plan
| Supported by grants from the Mexican Social Security Institute Foundation. The authors declare no conflicts of interest. |
Vol 156 - N° 5
P. 719 - mai 2010 Retour au numéro
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