Progressive Central Puberty in a Toddler with Partial Androgen Insensitivity - 20/02/14
Doi : 10.1016/j.jpeds.2013.11.020
Grace C. Dougan, MD 1, Naveen Uli, MD 2, Dorothy I. Shulman, MD 1, ⁎ 
1 Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL
2 Department of Pediatrics, Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, OH
∗Reprint requests: Dorothy I. Shulman, MD, 12901 Bruce B. Downs Boulevard, MDC 62, Tampa, FL 33612.
Abstract |
A male infant was diagnosed with partial androgen insensitivity caused by a novel mutation in the androgen receptor. At 3.5 months of age, he received 100 mg of testosterone intramuscularly over the course of 3 months to increase phallic size. He developed pubic hair after 5 months and signs of progressive central precocious puberty when re-examined at 17.5 months, which subsequently was suppressed with depot leuprolide.
Le texte complet de cet article est disponible en PDF.Keyword : AR, GnRHa, H-P, LH, PAIS, T
Plan
| The authors declare no conflicts of interest. |
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Vol 164 - N° 3
P. 655-657 - mars 2014 Retour au numéro
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