Bedside to Bench: The Risk of Bleeding with Parenteral Omega-3 Lipid Emulsion Therapy - 20/02/14
Doi : 10.1016/j.jpeds.2013.10.066
Bryan J. Dicken, MSc, FRCSC, FAAP 1, ⁎ 
, Aisha Bruce, FRCPC 2, 4, Tarah M. Samuel, ANP 3, Paul W. Wales, MSc, FRCSC 4, 6, Susan Nahirniak, FRCPC 7, Justine M. Turner, PhD, FRACP 3, 4, 5
, Aisha Bruce, FRCPC 2, 4, Tarah M. Samuel, ANP 3, Paul W. Wales, MSc, FRCSC 4, 6, Susan Nahirniak, FRCPC 7, Justine M. Turner, PhD, FRACP 3, 4, 5 1 Pediatric General Surgery, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada
2 Pediatric Hematology and Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada
3 Pediatric Gastroenterology, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada
4 Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
5 Department of Agriculture, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada
6 Pediatric General Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
7 Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
∗Reprint requests: Bryan J. Dicken, MSc, FRCSC, FAAP, Assistant Professor of Surgery, 2C3.44 WMC, 8440-112 Street, Edmonton, Alberta T6G 2B7, Canada.
Abstract |
Our clinical experience led us to reassess the effect of sole omega-3 lipid therapy on hemostasis. We compared thromboelastography platelet mapping in neonatal piglets given sole omega-3 lipid. We identified abnormalities in reaction time (P = .025) and the arachidonic acid pathway (P = .025). The potential for bleeding complications from parenteral omega-3 lipid emulsion therapy in high-risk infants with liver disease has been dismissed but, on the basis of this data, should be reconsidered.
Le texte complet de cet article est disponible en PDF.Keyword : AA, CVC, IFALD, MA, O3FA, TEG, TxA2
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| The authors declare no conflicts of interest. |
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Vol 164 - N° 3
P. 652-654 - mars 2014 Retour au numéro
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